About xerese

How Xerese Cream fights cold sores

Antiviral PLUS a clinically proven anti-inflammatory

The role of inflammation


Immune cells mobilize to fight a foreign invader, like the cold sore virus, and release chemicals that cause inflammation. This helps isolate the foreign substance and prevent it from spreading to other parts of the body. The symptoms of inflammation are redness, swelling, tenderness and pain.

Xerese is the first and only cold sore medication that combines an antiviral drug (acyclovir) and an anti-inflammatory drug (hydrocortisone) in one easy-to-apply cream.

Acyclovir blocks the HSV-1 virus from replicating, or copying itself. Because the virus can no longer replicate, the cold sore outbreak is shortened. Acyclovir is the same antiviral medication used in Zovirax® ointment and gel.

Hydrocortisone is a clinically proven treatment to reduce inflammation. Xerese reduces symptoms such as lesion size and tenderness.

What makes Xerese different, Learn about its dual action
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1. National Institutes of Health. MedLine Plus. Immune response. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/000821.htm. Accessed July 2, 2013.
2. XERESE® (acyclovir and hydrocortisone) cream 5%/1% Prescribing Information. January, 2014.
3. Raborn GW and Grace MGA. Recurrent herpes simplex labialis: selected therapeutic options. J Can Dent Assoc 2003;69(8):498-503.

*This offer is only valid for patients with commercial insurance. Eligible uninsured patients will pay more. This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. This offer is good only in the U.S. at retail pharmacies owned and operated by Walgreen Co. (or its affiliates) or other participating independent retail pharmacies. This offer is not valid in Massachusetts or Minnesota or where otherwise prohibited, taxed or otherwise restricted. Click here for other terms and conditions that apply.