If you see your cold sore as a BIG deal
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Indication and Important Safety Information
XERESE® (acyclovir and hydrocortisone) Cream 5%/1% is indicated for the early treatment
of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and
to shorten the lesion healing time in adults and adolescents (12 years of age and older).
XERESE Cream is intended for cutaneous use only, on the lips and around the mouth.
XERESE should not be used in the eye, inside the mouth or nose, or on the genitals. Patients
should be encouraged to seek medical advice when a cold sore fails to heal within 2 weeks.
The effect of XERESE Cream has not been sufficiently established in immunocompromised
patients. XERESE Cream has a potential for irritation and contact sensitization. In clinical
trials, the most common adverse reactions in the area of the application site included drying or
flaking of the skin; burning or tingling following application; erythema; pigmentation changes;
application site reaction including signs and symptoms of inflammation. Each event occurred in
less than 1% of patients.